Genesis 25:21

Isaac prayed to ¹  the Lord on behalf of his wife because she was childless. The Lord answered his prayer, and his wife Rebekah became pregnant.

Ge 11:30; Ge 15:2,3; Ge 16:2; Ge 17:16-19; 1Sa 1:2; 1Sa 1:11,27; 1Ch 5:20; 2Ch 33:13; Ezr 8:23; Ps 50:15; Ps 65:2; Ps 91:15; Ps 145:19; Pr 10:24; Isa 45:11; Isa 58:9; Isa 65:24; Lu 1:7; Lu 1:13; Ro 9:10-12

¹ tn The Hebrew verb עָתַר (’atar), translated “prayed [to]” here, appears in the story of God’s judgment on Egypt in which Moses asked the Lord to remove the plagues. The cognate word in Arabic means “to slaughter for sacrifice,” and the word is used in Zeph 3:10 to describe worshipers who bring offerings. Perhaps some ritual accompanied Isaac’s prayer here.