aggravating, annoying, backbreaking, besetting, bothering, burdensome, chafing, crushing, disquieting, distressful, distressing, disturbing, exasperating, fretting, galling, grueling, harassing, heavy, hefty, importunate, importune, irking, irksome, irritating, onerous, oppressive, painful, pesky, pestering, pestiferous, pestilent, pestilential, plaguesome, plaguey, plaguing, provoking, teasing, tiresome, tormenting, troublesome, troubling, trying, upsetting, vexatious, vexing, wearisome, worrisome, worrying

For further exploring for "bothersome" in Webster Dictionary Online

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