Genesis 22:2

22:2 God said, “Take your son – your only son, whom you love, Isaac – and go to the land of Moriah! Offer him up there as a burnt offering on one of the mountains which I will indicate to you.”

Genesis 22:12

22:12 “Do not harm the boy!” the angel said. “Do not do anything to him, for now I know that you fear God because you did not withhold your son, your only son, from me.”

Genesis 27:1

Jacob Cheats Esau out of the Blessing

27:1 When Isaac was old and his eyes were so weak that he was almost blind, he called his older son Esau and said to him, “My son!” “Here I am!” Esau replied.

Genesis 27:42

27:42 When Rebekah heard what her older son Esau had said, she quickly summoned her younger son Jacob and told him, “Look, your brother Esau is planning to get revenge by killing you.

Genesis 43:29

43:29 When Joseph looked up and saw his brother Benjamin, his mother’s son, he said, “Is this your youngest brother, whom you told me about?” Then he said, “May God be gracious to you, my son.”